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Here, GIP receptor activation may contribute to the increase in heart rate and reduction in arterial blood pressure observed after GIP administration ( In bone, exogenous and endogenous GIP is found to decrease bone resorption by reducing osteoclast activity and improving osteoblast survival ( Finally, infusion of GIP increases the deposition of triacylglycerol in adipose tissue ( 1.2 GIP receptor signaling pathways The actions of GIP are mediated by the GIP receptor, a G protein-coupled receptor (GPCR) in the class B1 receptor family ( s subfamily
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However, the Summary of Product Characteristics for these medications typically notes that clinical experience in patients aged 75 years and older is limited, and caution is advised in this population
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