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GLP-1 medications get at the heart of addiction: study | Office of Neuroscience Research | Washington University in St. Louis

In pancreatic α-cells, PC2 cleaves proglucagon to yield mature glucagon (29 aa), glicentin-related pancreatic polypeptide (GRPP) and the major proglucagon fragment (MPGF)

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The ultimate goal in addressing overweight and obesity must be to “bend the curve” – to prevent the projected rise to 3.8 billion adults living with overweight or obesity by 2050, and in doing so, reduce the associated burden of chronic disease and economic cost, which could exceed $4 trillion annually by 2035