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Pancreatic β-Cell Biology Research In cultured isolated pancreatic islets and cell lines, the compound is applied to analyze how oral GLP-1R agonists impact insulin secretion, β-cell survival, and the expression of function-associated genes (like PDX-1, MafA, and insulin genes)
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These include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), tirzepatide (Mounjaro, Zepbound—a dual GIP/GLP-1 agonist), exenatide (Byetta, Bydureon BCise), and lixisenatide (Adlyxin)
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