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Tolerance development timeline: Weeks 1 to 4: maximum appetite suppression, rapid initial weight loss (often 60% of total loss happens here) Weeks 5 to 12: partial tolerance develops, weight loss slows Weeks 13 to 24: weight stabilizes at new baseline, 10 to 30% below peak suppression Months 6 to 24: slow continued weight loss or stable maintenance About 30% of patients develop enough tolerance that appetite returns close to baseline by month 6

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They are subtle recalibrations