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From a nutrition and lifestyle standpoint, key unanswered questions include how these agents influence eating patterns, diet quality, and macro- and micronutrient intake over time, and whether specific dietary changes, particularly in protein intake, affect body composition during weight loss with GLP-1 therapies
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(2026, Clinical Obesity) reviewed six studies covering 480,825 adults on GLP-1 medications and found that nutritional deficiencies are common — vitamin D deficiency hit 13.6% at 12 months, iron depletion was frequent (26–30% lower ferritin vs comparators), and B vitamin deficiencies rose steadily over treatment
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