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Similarly to mice treated at RT, this is indicative of an initial increase in lipid oxidation followed by an increase in carbohydrate oxidation, although compared with mice at RT, elevated lipid oxidation in mice at TN occurred later during the transition from the rapid to the gradual weight loss period and abruptly ended during the transition to the weight maintenance period, whereas carbohydrate oxidation was significantly lower during the rapid weight loss period and increased during the gradual weight loss period (Fig