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A recent study conducted on 41 diabetic patients demonstrated that exposure to the GLP-1 RA dulaglutide over a 48-week period was associated with a substantial decrease in non-butyrate-producing Firmicutes (e.g., Ruminococcus and Blautia ), accompanied by an increase in Bacteroides, Lactobacillus , and Prevotella (74)

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02Exenatide, derived from Gila monster venom and approved in 2005, validated GLP-1 receptor agonism as a therapeutic strategy