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In vitro studies on bone cells supported the expression of the conventional GLP-1R in osteoblasts and confirmed that liraglutide, at nanomolar concentrations, promoted osteoblast differentiation and reduced osteoblast apoptosis via activation of the PI3K/Akt/GSK3K, MAPK, and cAMP/PKA/β-catenin intracellular pathways [46–48]
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