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Researchers from Boston Children’s Hospital have found that blocking, rather than activating, the GLP-1 receptor triggers the body’s innate defensive immune response to the development of colorectal cancer via a mouse model
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Both disproportionality analyses confirmed this heightened risk: ROR analysis showed a statistically significant association (ROR = 1.81, 95% CI 1.62–2.03), while BCPNN yielded an information component of IC = 0.85 (IC025 = 0.69), both indicating substantially greater renal impairment risks in this older population treated with the combination therapy
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