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3.1.2 Anti-inflammatory and immunomodulatory effects Chronic hepatic inflammation, driven by activated Kupffer cells, infiltrating macrophages, and pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF- α ) and interleukin-6 (IL-6), is a crucial factor in MASLD progression to steatohepatitis and fibrosis
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Hormonal changes with weight loss : Significant weight loss itself may influence hormone levels, including sex hormones such as testosterone and oestrogen
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