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Recent studies have indicated that T-cell receptor (TCR)αβ and TCRγδ-positive IELs express GLP-1R, and their treatment with exendin-4, a GLP-1RA, activates cyclic adenosine monophosphate (cAMP) pathway and suppresses the release of pro-inflammatory cytokines (IL-2, IL-17A, TNF-α and IFN-γ) (figure 3) [128,129]
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