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Both medications are metabolized through different routes—metformin is largely excreted unchanged by the kidneys, while tirzepatide undergoes peptide degradation—further reducing interaction risk

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Dose or concentration:2.5 mg 0.5mg/ml 4ml

Clinical trial participants who took Zepbound lost an average of 50 pounds over 72 weeks, while those who took semaglutide, or Wegovy, lost about 33 pounds