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Perioperative anesthesia and aspiration-related outcomes in patients receiving GLP-1 receptor agonists undergoing urgent and elective procedures: a systematic review - ScienceDirect
58 GLP-1RAs potentially may reduce the risk of AF onset and progression through direct and indirect effects on atrial remodelling, including a reduction in systemic inflammation, improvement of cardiomyocyte metabolism, autonomic nervous system modulation, regulation of intracellular Ca 2+ levels and prevention and possibly reversion of atrial fibrosis
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Although the precise role of granule acidification in priming granules for exocytosis is unknown, it is hypothesized that a low granular pH may induce a conformational change in the SNARE proteins that facilitate membrane fusion [56]
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