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† According to 3 multicenter, randomized, double-blind, placebo-controlled obesity trials (BMI ≥30, or BMI ≥27 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo
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Advancements in stem cell therapy, namely pancreatic islet transplantation, have been noted, with recent trials demonstrating insulin independence in 60% of recipients after five years
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