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They revealed an inhibitory microcircuit within the LS projecting from the dorsal LS (dLS) to the ventral LS (vLS): GLP-1R neurons in the dLS directly inhibited neurons expressing estrogen receptor 1 (Esr1) in the vLS through GABAergic synapses

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There is also a risk of bowel obstruction that is at an even higher risk in patients already prone to gastrointestinal issues