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El GLP-1, una hormona incretina secretada por las células L intestinales en respuesta a la ingesta de alimentos, aumenta la secreción de insulina dependiente de la glucosa, suprime la liberación de glucagón y retrasa el vaciado gástrico, lo que ayuda al control de la glucosa postprandial
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A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors.²³ Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%.²⁴ These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities
