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This resistance occurs due to the desensitization of LEPR, caused by prolonged exposure to high leptin levels, which diminishes the receptors' ability to regulate appetite and energy expenditure effectively

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“We do not expect any short term impact on premiums from this proposal, and in fact, this proposal provides a significant savings for people who currently may be paying out of pocket for these medications,” said CMS Deputy Administrator and Director for the Center for Medicare Meena Seshamani, M.D