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Every medication used in this program requires a gradual upward titration to minimize side effects, protect patient comfort, and allow the body to adapt to changes in appetite signaling and gastrointestinal function
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The trial did report a skin-related effect, described as cutaneous hyperesthesia and skin sensitivity, in about 7% of people on retatrutide compared with 1% on placebo, but it did not report alopecia or hair loss as a distinct side effect
