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Within the gut–brain framework, enteroendocrine cells act as chemosensory sentinels that translate luminal cues into endocrine and paracrine signals detected by vagal afferents, providing a concrete route through which microbiota-derived signals could modulate neuroendocrine circuits relevant to therapeutic heterogeneity (68)

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Ninety six percent of the patients in both treatment groups completed the study in accordance with the protocol, and the vital status was known at the end of the study for 98.9% and 98.8% of the patients in the BYDUREON and placebo group, respectively