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When Initiating Pramlintide , Decrease Dose of Mealtime Insulin by 50% Pramlintide not only works to reduce glucose appearance via the mechanisms previously described but it may also lead to a reduction in food intake greater than anticipated by a patient newly starting pramlintide
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However, many patients still experience nausea when they eat larger portions than their body can comfortably process—even though they feel less hungry than before