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GLP-1 RAs: Safe, Effective, Possibly Protective in Acute Pancreatitis | Kshitij Thakur MD, MSc posted on the topic | LinkedIn
2.2.2 Pyroptosis Activation of the NLRP3 inflammasome is a critical trigger of pyroptosis, leading to gasdermin-mediated membrane pore formation and excessive release of pro-inflammatory cytokines such as IL-1β and IL-18
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The regulator said it conducted an independent assessment of the potential association between GLP-1 RAs and NAION, but found “available evidence was conflicting” and sought advice from the national advisory committee on medicines on whether the evidence required “additional risk-mitigation measures”
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