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Along with higher adiposity, rats infused with AC187 exhibited increased plasma insulin and plasma glucose compared to control rats, data that indicate a physiological role in glucose control and potentially insulin sensitivity [69] and contrast findings in isolated skeletal muscles from rats showing deterioration of glucose control following amylin stimulation [73]
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This "dual agonist" mimics the gut peptides glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
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