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Supplementary material The Supplementary Material for this article can be found online at: Supplementary Table 1 Clinical characteristics and laboratory findings of study participants at baseline and 12 months after GLP-1 receptor agonist initiation
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The Risk of Regain (RCT Data) Stronger evidence from the STEP 4 and SURMOUNT-4 trials shows that reducing GLP-1 exposure leads to a reversal of benefits: Semaglutide: Patients who switched to placebo (stopping) regained 6.9% of their weight within 48 weeks.³ Tirzepatide: Patients who stopped treatment regained 14.0% within one year.⁴ Post-hoc Analysis: 82% of patients regained at least a quarter of their lost weight within 12 months of cessation.⁵ Clinical Perspectives on Maintenance While weekly dosing remains the gold standard, a 2026 observational study from Scripps Health explored reduced frequency (every 2–6 weeks) in a very specific cohort:² The Subjects: 30 patients who had already reached a weight-loss plateau
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